Biloxi is a city in Harrison County, Mississippi, United States. The 2010 United States Census recorded the population as 44,054, and in 2016 the estimated population was 45,975. Along with the adjoining city of Gulfport, Biloxi is a county seat of Harrison County. It was first settled by French colonists.The city is part of the Gulfport-Biloxi metropolitan area and the Gulfport-Biloxi-Pascagoula, Mississippi Combined Statistical Area. Pre-Katrina, Biloxi was the third-largest city in Mississippi, behind Jackson and Gulfport. Due to the widespread destruction and flooding, many refugees left the city. Post-Katrina, the population of Biloxi decreased, and it became the fifth-largest city in the state, being surpassed by Hattiesburg and Southaven.The beachfront of Biloxi lies directly on the Mississippi Sound, with barrier islands scattered off the coast and into the Gulf of Mexico.